• Previous studies have demonstrated that the signal transduct

  2018-11-06

  

  Previous studies have demonstrated that the signal transduction pathways mediating ATF3 expression include c-Jun co-expressed with ATF3 in the nervous system after injury and stress (Hunt et al., 2012). The selective JNK/c-Jun inhibitor SP600125 fully blocks ATF3 induction in adult rat ganglion neur

• With the recent advent of iPS cells and their wide

  2018-11-06

  

  With the recent advent of iPS Histone Compound Library and their wide potential in the field of regenerative medicine, the propensity of differentiated, iPS-derived cells to revert back to a pluripotent phenotype is particularly topical (Pera, 2011). Hence, the ability to identify, and ultimately e

• In the experiments described in this report molecular and ce

  2018-11-06

  

  In the experiments described in this report, molecular and cellular processes downstream of SOX18 were studied in a non-endothelial background. Effects of SOX18 expression on ASCs were manifested in an endothelial-like cell morphology and responsiveness to forces exerted by laminar flow. SOX18 induc

• br Materials and methods br Results br Discussion

  2018-11-06

  

  Materials and methods Results Discussion Strategies aiming at controlled divergence of ASCs to specific differentiated cell types essentially rely on prolonged culture in the presence of specific sets of growth factors and/or matrix proteins (Zuk et al., 2001). Specific culture conditions w

• br Acknowledgments This study was

  2018-11-06

  

  Acknowledgments This study was funded by a grant provided by the Royan Institute. We thank Mr. Ehsan Janzamin for his unlimited assistance in the Flow Cytometry Laboratory, Dr. Abass Piryaei and Leila Sattarian in the Histology Laboratory, Mr. Chehrazi for statistical analysis, and Miss Saloomeh

• Induced HSCs were derived from

  2018-11-06

  

  Induced HSCs were derived from both mouse and human PSCs via intra-teratoma hematopoiesis, which provides a new tool for investigating the extrinsic and intrinsic factors of hematopoietic development (Amabile et al., 2013; Suzuki et al., 2013). We used this approach to confirm that OP9-Lhx2 promotes

• The DNA fingerprint of Lymph AD iPS cell line

  2018-11-06

  

  The DNA fingerprint of Lymph2-AD2-iPS cell line was identical to the parental lymphoblast line AD2-2 (Fig. 1D). Karyotype analysis was male (XY) and both lines exhibited a normal diploid chromosomal content (Fig. 1E). As depicted in the Dendrogram (Fig. 1F), the transcriptome of the parental lymphob

• Embryonic stem cells ESCs display

  2018-11-06

  

  Embryonic stem tetracycline hcl (ESCs) display two important characteristics: self-renewal, which allows them to be indefinitely expanded while maintaining the undifferentiated state, and pluripotency, which allows them to differentiate into almost all cell types. ESCs are able to differentiate into

• Our work implicates exosomes and the miRNAs they contain

  2018-11-06

  

  Our work implicates exosomes, and the miRNAs they contain, as crucial mediators of CDC-induced cardiac regeneration. CDCs exert diverse but coordinated effects: they recruit endogenous progenitor GSK2606414 and coax surviving heart cells to proliferate (Chimenti et al., 2010; Li et al., 2010; Mallia

• Here we report that transient expression of NKX

  2018-11-05

  

  Here, we report that transient expression of NKX2-1 functions as an inductive signal during thyroid-directed differentiation to convert AFE-stage order Cisplatin to thyrocyte-like cells that self-organize to epithelial, follicle-like structures in 3D Matrigel culture. This thyroid conversion effect

• To study the cellular and molecular events

  2018-11-05

  

  To study the cellular and molecular events of FTD3, we derived a disease model using human iPSCs from patients carrying the 31449G > C mutation in CHMP2B and isogenic controls generated via the CRISPR/Cas9 system with subsequent in vitro neuronal differentiation. Our model not only confirmed partly

• br General scheme and electrode configuration In the new Sof

  2018-11-05

  

  General scheme and electrode configuration In the new Soffron60 analyzer, axial (parallel to the guiding magnetic field) component of buy R406 energy is measured with electric cut-off method characterized by high resolution and reliability and allowing data cross-checking. Electron-optics scheme

• br Conclusion To summarize we

  2018-11-05

  

  Conclusion To summarize, we have developed a method for determining Young\'s modulus of the sample surface using an AFM with an optical system for detecting the position of the probe organized by the interferometric principle. We have obtained the temperature dependence for the spring constant of

• The survival rate in the experimental group was and the

  2018-11-05

  

  The survival rate in the experimental group was 100%, and the scar area was significantly smaller compared to the control group. The animals from this group exhibited complete epithelialization of the wound surface in all cases (Fig. 4b, c). A histological examination of the scar tissue also reveale

• The crude odds ratio OR of

  2018-11-05

  

  The crude odds ratio (OR) of participation in the NSE class once a month at baseline against poor SRH two years later was 0.53 (95% CI: 0.34–0.85). The OR after adjusting for age and sex was 0.49 (95% CI: 0.30–0.78). Even after NSE class participation once a month at baseline against poor SRH two ye

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