• Although H AZK me could be detected by ChIP

  2018-11-08

  

  Although H2AZK7me1 could be detected by ChIP at the transcriptional start site of a few differentiation markers (Fgf5, FoxA2, and Hand2) in E14 mES cells and the level of methylation decreased from those genes in response to retinoic acid-induced differentiation, we still do not know what H2AZK7me1

• For many who look to stem cells as a means

  2018-11-08

  

  For many who look to stem continine as a means to alleviate their suffering, or that of their loved one, such high expectations are unlikely to be met in the near future. Although the number of clinical trials for novel applications of stem cells has risen rapidly since 2004 (Li et al, 2013), the m

• Dibromo chloropropane DBCP is a banned

  2018-11-08

  

  1,2-Dibromo-3-chloropropane (DBCP) is a banned nematicide that has been shown to cause male infertility (Amann and Berndtson, 1986; Bjorge et al., 1995; Holme et al., 1991; Potashnik and Porath, 1995; Slutsky et al., 1999; Whorton et al., 1979). In exposed workers, DBCP is gonadotoxic resulting in a

• PDGs possess a specific architecture and

  2018-11-08

  

  PDGs possess a specific architecture and molecular signature that make them distinct from the pancreatic epithelium, instead resembling gastric stem cell glands. PDGs were also found to express and up-regulate TFF genes during injury. In the stomach TFF1 is normally found predominantly in the epithe

• br Resource table br Resource details Spastic

  2018-11-08

  

  Resource table Resource details Spastic paraplegia gene type 5 (SPG5) is an autosomal recessive subtype of hereditary spastic paraplegia caused by mutations in CYP7B1, a gene encoding for the cytochrome P-450 oxysterol 7-α-hydroxylase, essential for the liver-specific alternative pathway in bi

• br Conclusions The following are the supplementary

  2018-11-08

  

  Conclusions The following are the supplementary data relate to this article. Disclosure of potential conflicts of interest Acknowledgments We thank Fondazione Roma for continuous support. We also acknowledge Prof. Mara Riminucci, Prof. Luca Pierelli, Dr. C. Murdoch, Dr. Paola Iudicone and

• order EPZ015666 br Materials and methods br Results br Discu

  2018-11-08

  

  Materials and methods Results Discussion Others and we have demonstrated that ESC-based developmental modeling mimics a variety of neurodevelopmental events occurring in vivo using either 2-D or 3-D systems. In those studies, the hESC-based developmental model has been proposed to imitate e

• The four cell lines present

  2018-11-08

  

  The four cell lines present the typical morphology of pluripotent stem cells, growing in compact colonies, with tightly packed kisspeptin (Fig. 1B). They express the pluripotency markers SSEA4, SSEA3, TRA-1-81, TRA-1-60 and OCT3/4, assessed by flow cytometry (Fig. 2A), and OCT4, REX1, NANOG and SOX2

• In the work we present here we investigated how miR

  2018-11-08

  

  In the work we present here, we investigated how miR-29a influences iPSC generation in mouse and we analyzed canonical WNT signaling pathway and the pluripotency-related active DNA demethylation enzyme Tet1 in this context, both of which are known to be modulated by miR-29. Furthermore, we show evid

• We herein show that simple supplementation with

  2018-11-08

  

  We herein show that simple supplementation with doxycycline greatly improves both hESC/iPSC viability and self-renewal. In practice, doxycycline dramatically enhances hESC/iPSC expandability, and the effects continue for long time periods. The effects of doxycycline are mediated by direct activation

• Cip Kip proteins are expressed

  2018-11-08

  

  Cip/Kip proteins are expressed at higher levels in HSCs than in progenitor cells (Passegué et al., 2005). The role of p21Cip1 in HSCs is restricted to cell cycle regulation under stress conditions (van Os et al., 2007). p27Kip1 deficiency does not affect HSC numbers or HSC self-renewal, but alters t

• br Results br Discussion We have developed an automated

  2018-11-08

  

  Results Discussion We have developed an automated segmentation, classification, and localization measurement algorithm (Figure 7A) for analysis of confocal and two-photon microscopy images of HSCs, osteoblasts, and bone obtained through intravital microscopy of mouse bone marrow. In particular

• br Results br Discussion We previously showed

  2018-11-08

  

  Results Discussion We previously showed that metformin treatment enhances murine adult neurogenesis in vivo without depleting the endogenous NPC pool (Wang et al., 2012). This finding has led to studies to repurpose metformin as a neuroregenerative agent to treat the injured or degenerating ly

• Researchers are usually aware of the tissue

  2018-11-08

  

  Researchers are usually aware of the tissue that was initially used for isolation of MSCs, but there is evidence that accidental interchange of samples or contaminations with other herpes simplex virus can occur (Garcia et al., 2010; Torsvik et al., 2010). For established cell lines, some contamina

• The adult mammalian kidney is an organ with very low

  2018-11-08

  

  The adult mammalian kidney is an organ with very low cell cycling during homeostasis but remarkable proliferating capacity after injury. It is still unresolved whether the kidney contains bona fide stem cells. Humphreys et al. (2008) genetically marked cells using Six2, a transcription factor expres

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