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We next sought insight regarding the mechanism that
2018-11-12
We next sought insight regarding the mechanism that links regulation of pluripotency with that of enhanced maintenance of genetic integrity in pluripotent cells. The discovery that fully pluripotent ceramide cost can be derived by transduction of differentiated cells starting with four (Takahashi a
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br Materials and methods br Results br Discussion
2018-11-12
Materials and methods Results Discussion The roles of endogenous stem/progenitor integrin signaling pathway in adult pancreatic tissue homeostasis, acute/chronic injury response and tumor initiation remain uncertain. However, it is now clear that a subset of pancreatic duct cells are capab
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br Molecular changes associated with cell
2018-11-12
Molecular changes associated with buy Tedizolid HCl withdrawal have been described, but molecular mechanisms of terminal differentiation remain largely uncharacterized The transition to the terminally differentiated phenotype is accompanied by down-regulation of cell cycle factors and up-regulat
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glut1 Introduction Human bone marrow stromal cells hBMSCs al
2018-11-12
Introduction Human bone marrow stromal glut1 (hBMSCs, also known as bone marrow-derived mesenchymal stem cells) contain a population of progenitor cells, and a subpopulation of skeletal stem cells (hSSCs) known to be able to recreate cartilage, bone, stroma that supports hematopoiesis and marrow ad
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br Results br Discussion Our present data
2018-11-09
Results Discussion Our present data demonstrate four key events that are mediated by the aPKC-CBP pathway: (1) neurogenesis in young adult mice (3 months old) by, at least in part, preventing the death of newborn neurons; (2) maintenance of a stable rate of hippocampal neuronal differentiation
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Our functional analyses showed that CD expression inversely
2018-11-09
Our functional analyses showed that CD38 expression inversely correlated with time of onset and persistence of the graft, confirming and extending published results obtained in xenograft models (Glimm et al., 2001; Kerre et al., 2001; Mazurier et al., 2003). Interestingly, analysis of clonal dynamic
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Wnt-C59 br Introduction Acute myeloid leukemia AML comprises
2018-11-09
Introduction Acute myeloid leukemia (AML) comprises a biologically and genetically heterogeneous group of disorders characterized by the rapid expansion of immature myeloid blasts in bone marrow (BM) (Bene et al., 2015; Grimwade et al., 2016). Disease heterogeneity is well documented and patients
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br The subject of the study materials and
2018-11-09
The subject of the study, materials and experimental procedures The experiments were carried out at the T.I. Vyazemsky Karadag scientific station – Nature Reserve of RAS (Feodosia) in an enclosed concrete 27m×9m×4.5 m-sized pool. An adult Black Sea bottlenose dolphin (Tursiops truncatus) who had
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To our knowledge prior to our study only a single
2018-11-09
To our knowledge, prior to our study only a single study has investigated the influence of medicine for mental illnesses on re-employment chances. This study found medicine for mental illness to diminish re-employment chances (Rosholm & Andersen, 2010), which our results support. Additionally, we fo
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br Methods br Results Of
2018-11-09
Methods Results Of the 9434 included participants, 1179 (12.5%) had CKD. The mean eGFR in participants with and without CKD were 46±12mL/min/1.73m2 and 89±15mL/min/1.73m2 respectively. Among the 1179 participants with CKD, 1051 (89.1%) had stage 3 CKD, 85 (7.2%) had stage 4 CKD and 43 (3.7%) h
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Understanding how barrier tissues function
2018-11-09
Understanding how barrier tissues function is essential for the design of effective pharmaceutical compounds. Once these devices are transitioned from research to clinical use, and we have more accurate predictive models early on in the development process, we will likely see an end to the recent st
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Further study will be necessary to fully elucidate
2018-11-09
Further study will be necessary to fully elucidate the epidemiology of in vitro and in vivo susceptibility to β-lactam/β-lactamase inhibitor combinations globally and in other lineages of M. tuberculosis. The association between MDR and XDR clinical isolates and in vitro susceptibility to amoxicilli
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br Discussion This study compares proviral DNA in the earlie
2018-11-09
Discussion This study compares proviral DNA in the earliest stages of AHI between untreated vs. treated individuals in two cohorts with similar gender, ethnicity, setting, HIV subtype and baseline total and integrated HIV DNA values, and with the same HIV DNA quantification methods (Vandergeeten
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Due to the importance of ClfA as a virulence factor
2018-11-09
Due to the importance of ClfA as a virulence factor, the protein has been explored as a potential vaccine candidate. Recombinant ClfA induced an antibody response in mice (Josefsson et al., 2008) and mice immunized with ClfA presented with less severe arthritis compared to mice immunized with a cont
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br Identification of needs br Example applications br
2018-11-09
Identification of needs Example applications Design requirements Design In this section, we discuss the preliminary design of the proposed Mezuri platform architecture aimed at addressing the above derived engineering requirements. For the sake of expediency, the first prototype of the M
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