• The concept of metronomic chemotherapy began in the

  2019-06-20

  

  The concept of metronomic chemotherapy began in the 1990s, when Kerbel showed chemotherapeutic agents may be able to target tumor vessel endothelial cells. In 2000, Browder et al demonstrated a more frequent, lower dose of cyclophosphamide, i.e. anti-angiogenic schedule, could induce response in tum

• br Methods br Results br Discussion One of

  2019-06-20

  

  Methods Results Discussion One of the hallmarks of cancer is the ability of cancer Psora 4 to evade apoptosis. Inhibition of apoptosis not only enhances the survival of cancer cells but also facilitates their escape from chemotherapy [5]. Therefore, apoptosis regulatory mechanisms are prom

• Mitochondrial DNA Isolation Kit br Therapy for the CPVT br C

  2019-06-20

  

  Therapy for the CPVT Conflict of interest Acknowledgment This work was supported by Health Science Research grant from the Ministry of Health, Labour and Welfare of Japan for Clinical Research on Measures for Intractable Diseases (2016-032). Introduction Bradyarrhythmia is a serious ele

• More recently Brugada et al used flecainide to

  2019-06-20

  

  More recently, Brugada et al. [131]. used flecainide to identify the full extent of low-voltage electrogram activity in the anterior RV and RVOT and targeted this region for RFA. In all 14 BrS patients, RFA eliminated abnormal bipolar electrograms, normalized ST-segment elevation on right precordial

• The findings of Peck and colleagues are in

  2019-06-20

  

  The findings of Peck and colleagues are in major ways expected and apply to many developing countries. However, the quest for solutions must integrate many other important questions. To what extent is the report by Peck and colleagues specific for NCDs and not only a reflection of an overall non-opt

• It s finally a year by

  2019-06-20

  

  It\'s finally 2015: a year by the end of which extreme poverty and hunger are to be eradicated, maternal and child mortality are to be drastically reduced, and the trajectory of the global incidence of HIV, tuberculosis, and malaria are to be reversed. Much has been written about where the Millenniu

• Tambi n debemos tener presente el horizonte

  2019-06-20

  

  También debemos tener presente el horizonte en el que se inscriben colecciones como la aquí revisada. Si aceptamos que nos encontramos bajo un panorama de fragmentación del conocimiento y segmentación de las disciplinas, se muestra fundamental la recuperación de la toma de partida por la cultura, en

• Lelijveld and colleagues suggest that some catch up

  2019-06-19

  

  Lelijveld and colleagues suggest that some catch-up growth occurs after discharge, even outside the expected 1000-day window, in the absence of any specific intervention. The real question now is to establish how this spontaneous partial recovery after treatment for SAM can be improved. During treat

• br Cardiac imaging br Head

  2019-06-19

  

  Cardiac imaging Head-up tilt testing Head-up tilt (HUT) testing is recommended to judge an episode of syncope to be likely caused by VF by excluding neurally mediated syncope (NMS). However, NMS may coexist with Brugada syndrome [42]. We conducted HUT testing in 46 patients with type-1 Brugada

• The importance of the microenvironment for

  2019-06-19

  

  The importance of the microenvironment for cancer development and progression is now widely recognised, but it is worth reminding ourselves that this is a relatively young area of research. Anyone searching PubMed today using the terms “” will find over 22,000 scientific publications, with around 30

• INTRODUCCI N Nuestra hip tesis general es que durante

  2019-06-19

  

  INTRODUCCIÓN Nuestra hipótesis general es que durante el periodo 1982-1985 se constituyó en Guatemala una dictadura institucional fundacional de las fuerzas armadas similar AZD6738 la experiencia de Argentina (1976-1983), y que parte de esas semejanzas se deben, entre otras razones, a las relacione

• Para concluir plantear a que

  2019-06-19

  

  Para concluir, plantearía que todo esfuerzo por alcanzar la paz en cada una de estas tres etapas sería infructuoso si no se educa para la paz y para el posconflicto, educación que debe recibir toda sociedad civil para entender y afrontar los cambios futuros del país en todo orden, incluyendo los niv

• Fluoxymesterone Further extensive FISH and molecular studies

  2019-06-19

  

  Further extensive FISH and molecular studies failed to detect either BCR–ABL, PDGFRA, PDGFRB and FGFR1 rearrangements or NPM1 and FLT3 mutations, whereas c-KIT D816V Fluoxymesterone was found on PB and BM mononuclear cells. Moreover, allele-specific PCR demonstrated JAK2 V617F mutation on both PB an

• br The Editorial in about global health inequity raises

  2019-06-19

  

  The Editorial in about global health inequity raises some important issues. The global health beta adrenergic receptors long ago acknowledged the worldwide disparities in health, but it has failed to take action; most of the efforts have been made in reporting the disparities among specific popu

• br Cholera remains a serious global

  2019-06-19

  

  Cholera remains a serious global public health problem, disproportionately affecting poor individuals, causing illness and death for thousands of people each year. Cholera cases are on the rise, with 47% more cases reported to WHO in 2014 than in 2013. Innovative approaches to control the disease

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