• Collectively these data suggest the potential clinical utili

  2021-04-08

  

  Collectively, these data suggest the potential clinical utility of COMT inhibitors for the treatment of addiction disorders. Similar to current pharmacotherapies such as naltrexone, tolcapone's effects were not ethanol specific, therefore tolcapone may be effective in reducing other drug reinforced

• Mass spectrometry has previously been used to examine the pr

  2021-04-08

  

  Mass spectrometry has previously been used to examine the presence of Hyp in recombinant collagen, using hydrolysates to identify the individual imino acid, equivalent to an amino hedgehog signaling analysis [33], and also by analysis of mass changes to tryptic peptides [34]. The present study, how

• br Acknowledgements We would like to thank Dr Ron Mason

  2021-04-08

  

  Acknowledgements We would like to thank Dr Ron Mason (NIEHS, Research Triangle Park, NC) for helpful discussion regarding the analysis of CCl4 metabolism, to Dr Karla Thrall and Dr Rick Corley (Battelle) for helpful discussions regarding study design and data interpretation, and to Jim Merdink an

• The in vitro enantioselective metabolism of pesticides has

  2021-04-08

  

  The in vitro enantioselective metabolism of pesticides has been investigated by employing human liver microsomes, which are a reliable resource to perform MCL enantioselective risk assessment in humans (Carrão et al., 2019; de Albuquerque et al., 2018, 2016; Yao et al., 2016). The enantioselective

• br Results br Discussion Oxysterols and EBI have received gr

  2021-04-08

  

  Results Discussion Oxysterols and EBI2 have received growing attention in the field of immunology, with works highlighting an important role for EBI2 in immune cell migration. However, these studies are mainly limited to animal models (Chalmin et al., 2015, Hannedouche et al., 2011, Kelly et a

• In this study we implicate SCFFBXO

  2021-04-08

  

  In this study, we implicate SCFFBXO3 E3 ligase as a critical modulator of inflammation in atherosclerosis and demonstrate the efficacy of a small molecule FBXO3 inhibitor in suppressing inflammatory responses important in atherosclerosis. Specifically, individuals carrying a hypofunctioning genetic

• br Discussion The regulation of intracellular cholesterol

  2021-04-07

  

  Discussion The regulation of intracellular cholesterol levels is a biological process of vital importance for cellular function and integrity, and involves robust transcriptional and post-transcriptional mechanisms that are sensitive to metabolic feedback control. Amongst post-transcriptional mec

• br Abbreviations br Acknowledgements br Introduction Dopamin

  2021-04-07

  

  Abbreviations Acknowledgements Introduction Dopamine β-hydroxylase (DbH) is the enzyme catalysing the conversion of dopamine to norepinephrine, two important neurotransmitters involved in the central nervous system [1]. This enzyme has been isolated from bovine chromaffin granules as a tetr

• br Regulation of DGK activity Activation of the

  2021-04-07

  

  Regulation of DGK activity Activation of the DGKs is complex and unique for each DGK isotype. In most cases, DGKs must translocate to a membrane compartment to access DAG. However, translocation does not necessarily activate the enzyme [57]. In addition, DGK activity can be modified by other cofa

• Pyronaridine Tetraphosphate Aldehyde dehydrogenase has been

  2021-04-07

  

  Aldehyde dehydrogenase has been characterized as a cancer stem cell marker, which plays a key role in various biological processes in tumor, including cell proliferation, invasiveness and chemoresistance. Recent data of Abourbih et al reported that ALDH1 expression did not correlate with primary tum

• The first transcription factor TF known to interact with one

  2021-04-07

  

  The first transcription factor (TF) known to interact with one of the cis-acting GAREs is GAMYB protein, the expression of which is induced by GA in the aleurone OSI-930 of barley (HvGAMYB) (Gubler and Jacobsen, 1992). GAMYB is an important regulator of endosperm functions during seed development a

• br Conclusion Blueberry is becoming a

  2021-04-07

  

  Conclusion Blueberry is becoming a worldwide crop with the fastest rising consumer demand trends for its health benefits. However, the berry size is one of the key parameters for determining fruit quality and consumers’ preferences (Milic et al., 2018). Understanding the physiological and molecul

• Bindarit Recently it was reported that Crm is linked to spin

  2021-04-07

  

  Recently, it was reported that Crm1 is linked to spindle pole body (SPB) by Spc72 in Bindarit yeast [9]. Spc72 and Spc110 are two specific receptors of γ-tubulin complex (Tub4), which target Tub4 to SPB and mediate the nucleation of microtubules from SPB [20]. It was found that disrupting the intera

• Next we evaluated the therapeutic

  2021-04-07

  

  Next, we evaluated the therapeutic potential of compound () using the mouse model of collagen-induced arthritis (CIA model), which is the pathological model for RA. Consequently, oral once-daily dosing of 3 mg/kg reduced the overall progression of the clinical score, including inflammation and bone

• LY 2109761 Introduction The carnitine choline acyltransferas

  2021-04-07

  

  Introduction The carnitine/choline acyltransferase family is a family of enzymes that play diverse roles, ranging from (the regulation of) LY 2109761 and fuel metabolism in mitochondria and peroxisomes to the generation of the neurotransmitter acetylcholine. In mammals, this family consists of sev

16558 records 709/1104 page Previous Next First page 上5页 706707708709710 下5页 Last page