• br Acknowledgments We thank Dr Kathleen

  2021-10-25

  

  Acknowledgments We thank Dr Kathleen Sullivan of Merck Research Laboratories for providing the CHO-K1 BHQ expressing an NFAT-β-lactamase reporter and the Gα subunit Gqi5, Dr. Chen Liaw (Arena Pharmaceutical), Ms. Rebecca Kaplan, Mr. Frank Xiaodong Gan for technical assistance, Dr. Andrew Howard f

• br Experimental br Acknowledgments This research was support

  2021-10-25

  

  Experimental Acknowledgments This research was supported by the Korea Research Foundation (2013R1A1A2007509). The authors thank to Dr. Moon Ho Son (Dong-A Pharm. Co. Ltd) for hGPR119 agonist activity assay. We also thank to Pharmacal Research Institute and Central Laboratory of Kangwon Nationa

• br Restart of Stalled Replication Forks By

  2021-10-25

  

  Restart of Stalled Replication Forks By preventing the replisome from unwinding duplex DNA, ICLs stall progression of the replication fork, which in turn results in genomic instability 41., 42.. As in prokaryotes, the conventional mechanism of ICL repair in eukaryotes involves the combined activi

• br Conflict of interest statement br Acknowledgments This wo

  2021-10-25

  

  Conflict of interest statement Acknowledgments This work was funded in part by a grant from the National Institutes of Health, NIDDK award #DK61425 (to PWS). Introduction The efflux of toxic compounds from the cell by multidrug exporters is an important mechanism for cellular homeostasis a

• Ajzenman et al reported improved stability

  2021-10-25

  

  Ajzenman et al reported improved stability and postural parameters in ASD children after EAT. Other authors presented similar findings,61, 62, 63, 64 although the studies were conducted among children with CP, and reported improved muscle symmetry,, stability of the head and the trunk, motor functio

• Recent studies revealed that synthetic oligomeric A

  2021-10-25

  

  Recent studies revealed that synthetic oligomeric Aβ1-42 decreased GLT-1 expression and promoted mislocalization of GLT-1 from the cell surface of primary astrocytes, leading to glutamate dyshomeostasis in synapses (Abdul et al., 2009, Scimemi et al., 2013). To address the cause for reduction of ast

• br Discussion In the present

  2021-10-25

  

  Discussion In the present study, we have demonstrated the effect of a high-fat diet upon wild-type and glut3 pregestational female phenotype and shown that it leads to obesity due to an increase in white adipose tissue contributing to the overall fat mass. Despite this observed obesity along with

• Moreover we examined inhibition of GLI mediated mRNA express

  2021-10-25

  

  Moreover, we examined inhibition of GLI-mediated mRNA expression by 1. Colubrinic Aurora A Inhibitor I (1) inhibited the mRNA production of PTCH in PANC1 cells in the dose-dependent manner. This result clearly shows 1 inhibits GLI-mediated transcription (Fig. 6). Discussion In this study, we id

• Recently unimolecular multi functional peptides that combine

  2021-10-25

  

  Recently, unimolecular, multi-functional peptides that combine GLP-1RA activity with SGC 0946 receptor and/or GIP activity have been suggested as new therapeutic agents for glycaemic and weight control. In rodents, dual GIP and GLP-1 receptor agonists achieve significantly better glucose control an

• Teicoplanin australia Activation of FXR or TGR inhibits infl

  2021-10-23

  

  Activation of FXR or TGR5 inhibits inflammatory response via repressing NF-κB activity [1]. FXR is not expressed or expressed at a very low level in macrophages [45] (data not shown), but highly expressed in hepatocytes. In contrast, TGR5 is expressed in macrophages but not in hepatocytes. Our data

• The lack of biological activity

  2021-10-23

  

  The lack of biological activity of this family of compounds against T. cruzi is quite unexpected and cannot be attributable simply to the presence of a hydroxyl group at C-1. In fact, either compound 6 or risedronate (5), both bearing a hydroxyl group at C-1, are effective inhibitors of TcFPPS.21, 2

• Several studies have also suggested that Wnt signalling can

  2021-10-23

  

  Several studies have also suggested that Wnt signalling can in turn stimulate the transcriptional activity of Yap/Taz (Figure 2, Figure 3). In the Azzolin model, Yap/Taz not only block β-catenin signalling, but their association with Axin1 and/or β-catenin also maintains them in an inactivate state

• It has been known for some time that

  2021-10-23

  

  It has been known for some time that an oral salt load given to mammals induces a much greater natriuresis than the intravenous administration of an equivalent amount of saline (Carey et al., 1976, Singer et al., 1998). In addition, oral administration of salt to rats has been reported to augmented

• br Materials and methods br Results br Discussion

  2021-10-23

  

  Materials and methods Results Discussion In this study, we demonstrated that zaprinast (a cGMP-PDE inhibitor) induced the intracellular calcium mobilization in the fluoxetine hydrochloride coexpressing GPR35 and Gqi5, Gqo5, or Gα16. Induction of intracellular calcium mobilization by zaprin

• The HRTOF MS of showed a quasi molecular ion peak

  2021-10-23

  

  The HRTOF-MS of showed a quasi-molecular ion peak at / 525.3044 [M+Na], corresponding to a quasi-molecular formula of CHNONa (Calcd for CHNONa: 525.3053). IR absorptions at 1680 and 1522cm suggested the presence of amide functions. Based on an analysis of 1D and 2D NMR spectra, the presence of one p

16495 records 587/1100 page Previous Next First page 上5页 586587588589590 下5页 Last page