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Previous studies have shown that zinc interacts with
2022-05-07
Previous studies have shown that zinc interacts with other allosteric modulators at the glycine receptor (Kirson et al., 2013, McCracken et al., 2010, McCracken et al., 2013). Of note, the chelation of zinc via tricine decreases the effects of alcohol at α1-, α2-, and α3-containing glycine receptors
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Hepatic drug metabolizing enzymes and transporters expressio
2022-05-07
Hepatic drug-metabolizing induced pluripotent stem cells and transporters expression were regulated by nuclear receptors [19], [20], [21]. The effects of HFD-induced fatty liver on drug metabolizing enzymes in mice were recently studied, and the results provided a systematic evaluation of the change
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It is an aspiring task to apply the
2022-05-07
It is an aspiring task to apply the glutamate biosensor for in vivo measurements in fluoxetine hydrochloride tissue. Due to a relatively large size of the electrode used in this work, the biosensor fits only ex vivo applications. However, it is possible to apply platinum microelectrodes 50–100 μm i
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Throughout the last few decades evidence has
2022-05-07
Throughout the last few decades, evidence has accumulated indicating that NTTs, whose primary location is the cell surface, are subject to a series of regulatory processes of intracellular traffic to and from the membrane (Robinson and Jackson, 2016; Vaughan and Foster, 2013). In addition, lateral m
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br Acknowledgements br Introduction Glucagon a amino acid
2022-05-07
Acknowledgements Introduction Glucagon, a 29-amino mineralocorticoid receptor antagonists peptide, is released from the pancreatic islets, intestine and stomach. Glucagon is released under hypoglycemic conditions and then elevates blood glucose levels, serving as a major counter hormone [1].
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In mammals a major physiological role of the GHSR gene
2022-05-07
In mammals, a major physiological role of the GHSR gene appears to be in regulating food intake and energy homeostasis by partaking in the neuronal mechanisms involving neuropeptide Y and agouti-related protein (Nakazato et al., 2001, Chen et al., 2017). In our study, determination of the abundance
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Inhibitors of the G rdos effect include the Ca
2022-05-07
Inhibitors of the Gárdos effect include the Ca2+-channel blocker nitrendipine with an IC50 of ∼103nM (Ellory et al., 1992, Ellory et al., 1992); its mode of action is likely to be from direct blockage of K+ flux through the Gárdos channel (Ellory et al., 1992, Ellory et al., 1992), and the peptidic
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br The interrelationship between obesity and
2022-05-07
The interrelationship between obesity and galanin Numerous studies revealed that obesity and galanin may promote each other. On the one hand, galanin may increase the possibility of obesity of subjects via boosting their appetite and food intake. Acute injection with galanin or its agonist, galan
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Lentiviruses are associated with immunological impairment in
2022-05-07
Lentiviruses are associated with immunological impairment in their respective hosts, and both human immunodeficiency and feline immunodeficiency viral infections increase the likelihood of secondary bacterial infections [23], [24]. Recently, Kubes et al. [25] demonstrated that feline neutrophils exh
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To further investigate if GPR was the functional
2022-05-07
To further investigate if GPR40 was the functional target of these phenylpropiolic Boc-D-Asp(OtBu)-OH.DCHA analogs, GW-1100, a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells with an IC50 value equal to 1 μM, was used to inhibit agonist-induced intracellular calcium flux [15]
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The investigation in vitro revealed that aldolase as well
2022-05-07
The investigation in vitro revealed that aldolase, as well as FBPase, has affinity to α-actinin, one of the structural protein of the Z-line (Rakus et al., 2003a, Mamczur et al., 2005). Therefore, the existence of in vivo heterologous complex, consisting of aldolase, FBPase and α-actinin has been po
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Development of few more dihydroxy
2022-05-06
Development of few more dihydroxy-pyrimidine and N-methylpyrimidone analogues as HIV-integrase inhibitors was attempted involving substitution of variety of five- and six-membered rings via the introduction of a simple methyl substituent in the α-position of the C-2 side chains in order to improve p
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Here we examined Meckel s cartilage of mice where Setdb
2022-05-06
Here, we examined Meckel's cartilage of mice where Setdb1 was knocked out only in neural crest derived NPPB receptor with the purpose of investigating the roles of Setdb1 in Meckel's cartilage, a supportive tissue for mandible formation. We observed enlarged Meckel's cartilage that was a result of
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br Materials and methods br
2022-05-06
Materials and methods Results Discussion Both EMT of the tubular epithelial N6-Cyclopentyladenosine receptor and the activation of fibroblasts are critical factors in the pathogenesis and progression of renal interstitial fibrosis. Accumulating evidence implicates EMT in the onset and path
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Currently the computational chemical biology has been applie
2022-05-06
Currently, the computational chemical biology has been applied in hepatitis B antiviral drug discovery research [18]. Tan et al. explored oxime ethers as HBV inhibitors by docking and screening [19]. Allen et al. clarified the resistance of HBV to the nucleoside drug lamivudine [20]. The results sug
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