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Tension within the network could
2023-01-29
Tension within the network could be explained by two potential mechanisms: the more classical contractility that is dependent on motor proteins that are pulling AP26113 filaments towards each other [10]; or contractility that is caused by disassembly of a crosslinked network of actin filaments [2].
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To date the molecular responses
2023-01-29
To date, the molecular responses of AChE have been partially analyzed in its mRNA level or protein activity in aquatic animals. To understand the correlation between transcriptional change and activity of AChE, we conducted both experiments in B. koreanus. Generally, the ifenprodil synthesis patter
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br Materials and methods br Results br Discussions Our
2023-01-29
Materials and methods Results Discussions Our results indicated that autophagy was suppressed in GECs under HAGG treatment, through Akt/mTOR-dependent pathways. Previous reports provided clues for the linkages between ICs and endothelial cell autophagy. Fujii and colleagues reported that se
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Phagosomes acquire some hydrolases early during their journe
2023-01-29
Phagosomes acquire some hydrolases early during their journey from the cell surface to lysosomes. An example for such hydrolase is cathepsin H which is most concentrated in the early phagosome at a pH of approximately 6.3 (Claus et al., 1998), the pH optimum of enzyme activity (Schwartz and Barrett,
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In Pham et al employed the microsphere based technology to
2023-01-29
In 2014, Pham et al. [22] employed the microsphere-based technology to create a Luminex probe-based assay for the rapid identification of single nucleotide polymorphisms that are known to confer resistance to one or more echinocandins in C. glabrata. The targets for the FKS probes were generated usi
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br Materials and methods br Results br Discussion
2023-01-29
Materials and methods Results Discussion Our results revealed that LPS injection in rats impaired fear memory in the PA task. This results are in agreement with the most of previous studies reported that following acute [23,24,39,[45], [46], [47]] or chronic systemic Nanaomycin A receptor
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A unique finding in this study is that
2023-01-28
A unique finding in this study is that 12/15-LO influences CREB phosphorylation in the murine brain. While previous reports have found that knockout of 5-lipoxygenase, a related enzyme that also uses arachidonic MHY1485 for substrate, can regulate CREB phosphoryation in the context of Alzheimer's di
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Introduction Glaucoma consists of a group of eye diseases sh
2023-01-28
Introduction Glaucoma consists of a group of eye diseases showing a broad spectrum of clinical presentation and unknown aetiologies, that lead to a permanent loss of visual function due to the death of retinal ganglion PF-573228 synthesis and damage of the optical nerve. It is well accepted that a
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AMPK is a serine threonine protein kinase composed of a
2023-01-28
AMPK is a serine/threonine protein kinase composed of a catalytic α subunit with the activating phosphorylation site (Thr172) and two regulatory subunits, β and γ. The two AMPK variants, α1 and α2, show different cellular localization in mammalian cells. AMPKα2 is detected in nuclear and non-nuclear
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Hydroxyzine 2HCl receptor AMPK is an essential player in adi
2023-01-28
AMPK is an essential player in adiponectin signaling pathway that regulates energy metabolism. The fact that suppression of AMPK activity by compound C largely diminished candesartan-mediated inhibition of NFκB via blocking AT1 also suggests that the AT1-mediated effect is at least partly resulted f
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As an alternative to chronic receptor blockade
2023-01-28
As an alternative to chronic receptor blockade, we have been targeting adenosine kinase (ADK) – an astrocyte-based enzyme that catalyses the phosphorylation of adenosine, as a means to modify JSH-23 synthesis adenosinergic signalling (Boison, 2006, Etherington et al., 2009). Up-regulating ADK facil
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In model plant Arabidopsis there are myosin XI
2023-01-28
In model plant Arabidopsis, there are 13 myosin XI isoforms (XI-1, XI-2, XI-A, XI-B, XI-C, XI-D, XI-E, XI-F, XI-G, XI-H, XI-I, XI-J, and XI-K) and 4 myosin VIII isoforms (ATM1, ATM2, VIII-A, VIII-B) [9,13]. Arabidopsis myosin XIs have the common domain composition: a motor domain that interacts with
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br Experimental procedure br Introduction Migraine is a debi
2023-01-28
Experimental procedure Introduction Migraine is a debilitating neurovascular disorder characterized by recurring unilateral pulsating headaches of moderate to severe intensity, associated with nausea, photophobia and/or phonophobia, lasting from 4 to 72 h (Headache Classification Committee of
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Autophagy is a highly conservative intracellular bulk
2023-01-28
Autophagy is a highly conservative intracellular bulk degradation process including three major forms namely microautophagy, chaperone-mediated autophagy and macroautophagy. A large number of evidence has depicted a pivotal role for autophagy in the maintenance of cardiac geometry and contractile fu
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br The Molecular Machinery of Autophagy and Regulation
2023-01-28
The Molecular Machinery of Autophagy and Regulation by Sphingolipids Sphingolipid-Mediated Autophagy in Cancer: Dr. Jekyll and Mr. Hyde Autophagy is an evolutionarily conserved stress response that typically promotes survival and antagonizes apoptosis. However, excessive autophagy was found to
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