• br Results br Discussion We have developed

  2018-10-24

  

  Results Discussion We have developed an optimized and streamlined method for efficient engineering of targeted chromosomal translocations in human MSCs and iPSCs. We first generated an all-in-one plasmid system to co-express two sgRNAs, the Streptococcus pyogenes Cas9 flanked by two NLSs and a

• These organoid technologies have been pioneered for the smal

  2018-10-24

  

  These organoid technologies have been pioneered for the small intestine (Sato et al., 2009) and later extended also to other organs or parts of organs (Nakano et al., 2012). Recently, protocols for the generation of human brain-like organoids have been developed, including protocols for cerebral (La

• The solids refractive index is primarily specified by its ch

  2018-10-24

  

  The solids refractive index is primarily specified by its chemical composition. Indeed, a comparison between these indicators for the films of TiO2 and TiO2–CdO with the uniform thickness shows that the former is of higher value than the latter (1.97 against 1.91 [15]). However, the refractive index

• x y is a polynomial of

  2018-10-24

  

  (x, y) is a polynomial of a finite degree k, and S(x, y) is an arbitrary harmonic function,. In order to construct spectrographic media, we need homogeneous polynomials, and they can be expressed as a sum of terms . Then let us put and calculate Δg: It is clear that the polynomial with a degre

• Let us examine a thermodynamic model taking into account

  2018-10-24

  

  Let us examine a thermodynamic model taking into account the influence of interfacial tension on the reconstructive phase transition. Let us analyze an idealized case when the polycrystalline sample consists of spherical particles of radius R. Let us designate the Gibbs free Zebularine in the low-t

• The acoustic signals produced by dolphins Yana and Yasha wer

  2018-10-24

  

  The acoustic signals produced by dolphins Yana (1) and Yasha (2) were recorded with no special training and no food reward for the dolphins. The periods of time used was when the dolphins habitually swam to walkway 5 (located 0.1m above the water level), and remained afloat at the water surface with

• Specificity is also valuable in terms of operationalization

  2018-10-24

  

  Specificity is also valuable in terms of operationalization of variables and the conceputalisation of salient environmental correlates in different contexts and population groups. In a sample of 190 older adults in the USA, univariate analyses demonstrated a significant association between physical

• To illustrate the imprecision of a sequence

  2018-10-24

  

  To illustrate the imprecision of a sequence-insensitive approximation of health-related phone use, we regress delays in healthcare access against the four options to assess health-related mobile phone use and compare the estimated predicted changes of such phone use to the sequence-sensitive Option

• In this paper we use

  2018-10-23

  

  In this paper we use a database of 756 Direct Actions of Unconstitutionality (ADI) judged by the Brazilian Supreme Court (STF) from 2002 to 2012 to analyze the judicial behavior of this court\'s justices. ADIs can be initiated by a relatively broad list of actors (the President, the Attorney General

• If we apply this general concept to the

  2018-10-23

  

  If we apply this general concept to the four variables under consideration, γ, τ, φ and ζ, the new index is simply: , , and being the “revised” normalization of the original variables γ, τ, φ and ζ (such that the maximum value assumed by this index is indeed 1). More precisely, A final word is n

• Furthermore the inhibitor binding can also

  2018-10-23

  

  Furthermore, the inhibitor binding can also be altered by various mutations. Prime examples are acquired intrinsic resistance mutations that have marred the success of tyrosine kinase inhibitors (TKIs) such as gefitinib, erlotinib and imanitib, prompting efforts for second- and third-line treatments

• Although technological improvements in terms of specimen acq

  2018-10-23

  

  Although technological improvements in terms of specimen acquisition and processing have been made, much work remains to be done to ensure the quality of biospecimens and harmonization of tissue collection, processing and storage procedures, attributable largely to the long-standing success of forma

• With the discovery of the phospholipase A receptor PLAR

  2018-10-23

  

  With the discovery of the phospholipase A receptor (PLAR) and thrombospondin type-1 domain-containing 7A (THSD7A) as target antigens in 80% of patients with primary membranous nephropathy clinical and experimental research as well as patient management can be better adapted to the pathophysiology of

• Among the ten key recommendations in a

  2018-10-23

  

  Among the ten key recommendations in a recent Lancet report is to strengthen the detection of early-stage liver disease, which is essential to reduce disease progression (Williams et al., 2014). Analysis of volatiles in the breath has the potential to deliver this, but only if chemical compounds can

• The MERS virus which emerged in is now considered a

  2018-10-23

  

  The MERS virus, which emerged in 2012, is now considered a threat to global public health. Developing an effective vaccine is important to control MERS-CoV infection. To date, virus-vector vaccines, such as recombinant modified vaccinia virus Ankara (MVA), which expresses full-length MERS-CoV spike

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